3D Chromatin

As variants identified through GWAS often fall in non-coding regions, we have used promoter capture HiC to link the effects of long distance interactions between enhancers and gene promoter regions.

Integrating this information with gene expression and somatic mutation data, we are able to identify those regions that affect cellular and molecular responses.

We are further exploring these areas with cutting edge molecular technologies to improve the resolution of the interactions.

Further Reading

G Orlando, PJ Law, AJ Cornish, SE Dobbins, D Chubb, P Broderick, ...; 2018; Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer; Nature Genetics; 50 (10), 1375-1380 PMID: 30224643

R Jäger, G Migliorini, M Henrion, R Kandaswamy, HE Speedy, A Heindl, ...; 2015; Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci; Nature Communications; 6 (1), 1-9 PMID: 25695508